Phospho-PCAF (Tyr729) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105083-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105083 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-PCAF (Tyr729)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KAT2B
Gene Alias
A930006P13Rik; AI461839; AW536563; CAF; CREBBP-associated factor; histone acetylase PCAF; Histone acetyltransferase KAT2B; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Kat2b; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Pcaf; Spermidine acetyltransferase KAT2B
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18519, 301164, 8850
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q92831, Q9JHD1
Gene Symbols
KAT2B
Immunogen
A synthesized peptide derived from human KAT2B(Accession Q92831), corresponding to amino acid residues around phosphorylated Tyr729.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of PCAF only when phosphorylated at Tyr729
- PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation
- It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles
- PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5
- It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A
- PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers
- It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.