Phospho-c-Mpl (Tyr626) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105170-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105170 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-c-Mpl (Tyr626)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MPL
Gene Alias
CD110; c-mpl; hlb219; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; THCYT2; thrombopoietin receptor; TPOR; TPO-R
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17480, 366455, 4352
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P40238, Q08351
Gene Symbols
MPL
Immunogen
A synthesized peptide derived from human MPL(Accession P40238), corresponding to amino acid residues around phosphorylated Tyr626.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of TPOR only when phosphorylated at Tyr626
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages
- In 1992 the human homologue, named, c-mpl, was cloned
- Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily
- Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation
- The ligand for c-mpl, thrombopoietin, was cloned in 1994
- Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation
- The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs
- TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation
- Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.