Phospho-CDK9 (Thr186) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105181-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105181 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-CDK9 (Thr186)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDK9
Gene Alias
C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1025, 107951, 362110
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P50750, Q641Z4, Q99J95
Gene Symbols
CDK9
Immunogen
A synthesized peptide derived from human CDK9(Accession P50750), corresponding to amino acid residues around phosphorylated Thr186.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of CDK9 only when phosphorylated at Thr186
- CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex
- This complex plays a key role in regulating the eukaryotic cell cycle
- CDK9 is coexpressed and copurified with CyclinT1
- CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors
- CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis
- The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro
- Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.