PIPA5114704
Bcl-rambo Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114704-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114704 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Bcl-rambo
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BCL2L13
Gene Alias
BCL2 like 13; BCL2L13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; Bcl-rambo; CD003; E430016C20Rik; MIL1; Mil-1; mitochondria located 1 homolog; protein Mil1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23786
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (PFA fixed), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q9BXK5
Gene Symbols
BCL2L13
Immunogen
A synthesized peptide derived from human BCL2L13(Accession Q9BXK5), corresponding to amino acid residues S208-A258.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total BCL2L13
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells
- Disruption of this process has been implicated in a variety of diseases such as cancer
- Members of the Bcl-2 family are known to be critical regulators of this process
- These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains
- A novel, widely expressed member termed Bcl-rambo was recently identified
- This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2
- Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion
- This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.