SNX6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5115946-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5115946 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SNX6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SNX6
Gene Alias
2010006G21Rik; 2610032J07Rik; 2810425K19Rik; AU018928; C85963; MSTP010; SNX6; sorting nexin 6; sorting nexin-6; Sorting nexin-6, N-terminally processed; TFAF2; TRAF4-associated factor 2; tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
362738, 58533, 72183
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q6P8X1, Q9UNH7
Gene Symbols
SNX6
Immunogen
A synthesized peptide derived from human SNX6(Accession Q9UNH7), corresponding to amino acid residues F216-F266.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total Snx6
- SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases
- These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal
- Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII
- Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI
- SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences
- Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases
- Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes
- These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.