TRPC4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117080-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117080 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TRPC4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Trpc4
Gene Alias
alpha TRPC4, beta TRPC4, beta-2 TRPC4, capacitative calcium entry channel 1, capacitative calcium entry channel Trp4, CCE1, HTRP4, HTRP-4, MGC119570, MGC119571, MGC119572, MGC119573, putative capacitative calcium entry channel, receptor-activated cation channel TRP4, Short transient receptor potential channel 4, STRPC4, transient receptor potential cation channel subfamily C member 4, transient receptor potential cation channel, subfamily C, member 4, transient receptor potential channel 4, transient receptor potential protein 4, transient receptor protein 4, Trp4, TRPC 4, Trpc4, Trpc4_v2, trp-related protein 4, Trrp4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22066, 7223
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
2.46 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9QUQ5, Q9UBN4
Gene Symbols
Trpc4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_0572631)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: SKOV3, BT-474, HeLa, Mouse brain Immunogen sequence: SKESSNSADS DEKSDSEGNS KDKKKNFSLF DLTTLIHPRS AAIASERHNI SNGSALVVQE PPREKQRKVN FVTDIKNFGL FHRRSKQNAA EQNANQIFSV SEEVARQQAA GPLERNIQLE SRGLASRGDL SIPGLSEQCV LVDHRERNTD TLGLQVGKRV CPFKSEKVVV EDTVPIIPKE KHAKEEDSSI DYDLNLPDTV THEDYVTTRL TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels
- TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation
- Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity
- Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4
- The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel
- TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7)
- Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel
- The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel
- The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels
- CaV3.3 may be involved in calcium signaling in neurons
- Alternate splicing results in multiple transcript variants of CaV3.3
- Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression
- Diseases associated with CACNA1I include Childhood Absence Epilepsy.