BMPR2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA521437-Each-of-1 | In Stock | ₹ 52,332.00 |
PIPA521437 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
BMPR2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Bmpr2
Gene Alias
2610024H22Rik; AL117858; AW546137; BB189135; BMP type II receptor; BMP type-2 receptor; BMP-2; BMPR2; BMPR-2; BMPR3; BMPRII; Bmpr-II; BMR2; bone morphogenetic protein receptor type 2; bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272; POVD1; PPH1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12168, 140590, 659
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.17 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
O35607, Q13873
Gene Symbols
Bmpr2
Immunogen
Recombinant fragment corresponding to a region within amino acids 667 and 951 of BMPR2 (Uniprot ID#Q13873)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HUVEC
- Predicted reactivity: Mouse (92%), Rat (92%), Pig (92%), Chicken (86%), Sheep (93%), Rhesus Monkey (98%), Bovine (93%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases
- The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis
- The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation
- BMPs are involved in endochondral bone formation and embryogenesis
- These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa
- Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding
- Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.