ALAS1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529966-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA529966 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
ALAS1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ALAS1
Gene Alias
5'-aminolevulinate synthase 1; 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALA-S; ALAS1; Alas-1; ALAS3; ALASH; Alas-h; ALAS-N; aminolevulinate synthase H; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1; MIG4; migration-inducing protein 4; OK/SW-cl.121; succinyl-CoA: glycine C-succinyl transferase
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
211
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.71 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P13196
Gene Symbols
ALAS1
Immunogen
Recombinant fragment corresponding to a region within amino acids 62 and 304 of Human ALAS-H
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Raji
- Predicted reactivity: Mouse (87%), Rat (85%), Bovine (85%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA
- It regulates the first and rate-limiting step of heme biosynthetic pathway
- It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme
- It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins
- ALAS1 in liver undergoes negative feedback regulation by heme
- Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression
- ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders
- ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.