Fibronectin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588871-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA588871 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Fibronectin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
FN1
Gene Alias
Anastellin, CIG, Cold insoluble globulin (CIG), Cold-insoluble globulin, cumulus cell-specific fibronectin 1 transcript, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149, E330027I09, ED-B, embryo-specific fibronectin 1 transcript, ferritin L subunit, ferritin L-chain, FIBNEC, fibronectin, fibronectin 1, fibronectin ED-A- region, fibronectin ED-B+ region, fibronectin variable region, FINC, FN, FN1, fn-1, FNZ, GFND, GFND2, LETS, LOW QUALITY PROTEIN: fibronectin, Migration stimulating factor (MSF), migration-stimulating factor, MSF, Ugl-Y1, Ugl-Y2, Ugl-Y3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2335, 25661
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
2.05 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P02751, P04937
Gene Symbols
FN1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 2169-2355 of human Fibronectin (NP_0020171)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: U-87MG, NIH/3T3; Cellular Location: extracellular matrix, extracellular space Immunogen sequence: QPTDDSCFDP YTVSHYAVGD EWERMSESGF KLLCQCLGFG SGHFRCDSSR WCHDNGVNYK IGEKWDRQGE NGQMMSCTCL GNGKGEFKCD PHEATCYDDG KTYHVGEQWQ KEYLGAICSC TCFGGQRGWR CDNCRRPGGE PSPEGTTGQS YNQYSQRYHQ RTNTNVNCPI ECFMPLDVQA DREDSRE Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa
- In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers
- Fibronectin is most abundant during embryonic development and tissue remodeling
- Fibronectin is also present at high concentrations as a soluble plasma protein
- Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g
- collagen and heparin) and receptors on cells (e.g
- integrins)
- Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix
- Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis
- Fibronectin has been implicated in carcinoma development in lung cancer
- Further, Fibronectin expression is increased especially in non-small cell lung carcinoma
- The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents
- The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants
- However, the full-length nature of some Fibronectin variants has not been determined.