PKC beta-1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595606-Each-of-1 | In Stock | ₹ 46,057.50 |
PIPA595606 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
PKC beta-1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Prkcb
Gene Alias
A130082F03Rik, Pkcb, PKC-B, PKC-Beta, Prkcb, Prkcb1, PRKCB2, protein kinase C beta, protein kinase C beta I, protein kinase C beta II, protein kinase C beta type, protein kinase C beta-II, protein kinase C, beta, protein kinase C, beta 1, protein kinase C, beta 1 polypeptide
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18751, 25023, 5579
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
500 μg/mL
Formulation
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.
P05771, P68403, P68404
Gene Symbols
Prkcb
Immunogen
A synthetic peptide corresponding to a sequence of human PKC beta 1/PRKCB (NFDKEFTRQPVELTPTDKLFIMNLDQNE).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
- The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells
- The protein encoded by this gene is one of the PKC family members
- This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption
- Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress
- Alternatively spliced transcript variants encoding distinct isoforms have been reported.