Septin 2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596431-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596431 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Septin 2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SEPTIN2
Gene Alias
2-Sep, AW208991, DIFF6, hNedd5, KIAA0158, mKIAA0158, NEDD5, Nedd-5, Neural precursor cell expressed developmentally down-regulated protein 5, neural precursor cell expressed, developmentally down-regulated 5, neural precursor cell expressed, developmentally down-regulated gene 5, Pnutl3, Sept2, septin 2, Septin2, septin-2, Vascular endothelial cell specific protein 11, Vesp11
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18000, 4735
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.95 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
P42208, Q15019
Gene Symbols
SEPTIN2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 112-361 of human Septin 2 (NP_0043951)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RDCFKTIISY IDEQFERYLH DESGLNRRHI IDNRVHCCFY FISPFGHGLK PLDVAFMKAI HNKVNIVPVI AKADTLTLKE RERLKKRILD EIEEHNIKIY HLPDAESDED EDFKEQTRLL KASIPFSVVG SNQLIEAKGK KVRGRLYPWG VVEVENPEHN DFLKLRTMLI THMQDLQEVT QDLHYENFRS ERLKRGGRKV ENEDMNKDQI LLEKEAELRR MQEMIARMQA QMQMQMQGGD GDGGALGHHV; Positive Samples: 293T, HepG2, MCF7, HeLa, BT-474, BxPC-3, Mouse spleen, Mouse lung, Mouse ovary; Cellular Location: Cell projection, Chromosome, Cleavage furrow, Cytoplasm, Midbody, cell cortex, centromere, cilium membrane, cytoskeleton, kinetochore, spindle Septin 2 is a filament-forming cytoskeletal GTPase
- Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin
- It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression
- During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation
- Septin 2 also plays a role in ciliogenesis and collective cell movements.