01-675-852
SPHK2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-852-Each-of-1 | In Stock | ₹ 48,905.50 |
01-675-852 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SPHK2
Classification
Polyclonal
Formulation
PBS with 0.08% sodium azide
Gene Accession No.
Q9NRA0
Gene Symbols
Sphk2
Immunogen
Synthetic peptide corresponding to the N-terminal extension of Sphingosine Kinase 2-L.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Gene
Sphk2
Gene Alias
C76851; SK 2; SK2; SK-2; Sphingosine kinase 2; sphingosine kinase type 2; Sphk2; SPK 2; SPK-2; Spk2, Sk2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56848
Content And Storage
-80° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- A suggested positive control for this product is Jurkat cell lysate
- SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P)
- S1P signals through G-protein coupled receptors and controls diverse cellular processes
- Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer
- SPHK2 is an important signaling molecule with intra- and extracellular functions and has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis
- The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors)
- These receptors couple to multiple G proteins (e.g
- S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction
- Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells
- S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).