RNASE3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
RNASE3
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Mouse
Gene Accession No.
O35290
Gene ID (Entrez)
53876
Immunogen
Recombinant Mouse RNASE3 protein, Phe34-Val150 (Accession #O35290)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
cytotoxic ribonuclease, Ear11, EAR-11, Ear3, ECP, Eosinophil cationic protein, eosinophil cationic protein-like, eosinophil cationic-type ribonuclease 3, Eosinophil secondary granule ribonuclease 11, eosinophil-associated ribonuclease 3, eosinophil-associated, ribonuclease A family, member 3, LOC100361866, mR3, MR-3, murine ribonuclease 3, RAF1, Ribonuclease 3, ribonuclease A family member 3, ribonuclease, RNase A family 3, ribonuclease, RNase A family, 3, RNase 3, RNASE3, RNS3
Gene Symbols
Ear3
Isotype
IgG
Purification Method
Protein A
Gene
Ear3
Related Products
Description
- ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family
- ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system
- ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils
- ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities
- It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis and tremor that may lead to death
- ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases.