Cyclophilin A Monoclonal Antibody (C1), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Cyclophilin A
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
2700098C05, Cphn, CYCA, cyclophilin, Cyclophilin A, Cyclosporin A-binding protein, CyP A, CyP-18, CYPA, CyP-A, CYPH, EC 5.2.1.8, epididymis secretory sperm binding protein Li 69p, HEL-S-69p, HGNC:9253, I79_011869, MGC117158, MGC12404, MGC23397, p1B15, p31, Peptidyl-prolyl cis-trans isomerase A, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed, peptidylprolyl isomerase A, peptidylprolyl isomerase A (cyclophilin A), PPIA, PPIase, PPIase A, rotamase, rotamase A, SP18, T cell cyclophilin
Gene Symbols
Ppia
Isotype
IgG2a κ
Purification Method
Protein A/G
Gene
Ppia
Clone
C1
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Porcine, Rat
Gene Accession No.
P10111, P17742, P62936, P62937
Gene ID (Entrez)
25518, 268373, 397637, 5478
Immunogen
Recombinant Mouse CYPA protein, Val2-Leu164 (Accession #P17742)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506
- Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP)
- Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506
- Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds
- As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins
- Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC
- CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.