IL-5 Monoclonal Antibody (C1), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
IL-5
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
B-cell differentiation factor I, B-cell growth factor II, BCGF-II, colony-stimulating factor, eosinophil, cytotoxic T-lymphocyte inducer, EDF, Eosinophil differentiation factor, IL5, IL-5, ILN, Interleukin, Interleukin 5, Interleukin 5 (colony-stimulating factor eosinophil), Interleukin 5 (colony-stimulating factor, eosinophil), Interleukin5, interleukin-5, T-cell replacing factor, TRF
Gene Symbols
Il5
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
Il5
Clone
C1
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Rat
Gene Accession No.
P04401, P05113, Q08125
Gene ID (Entrez)
16191, 24497, 3567
Immunogen
Recombinant Human IL5 protein, Ile20-Ser134 (Accession #P05113)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils
- IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation
- The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes
- The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF)
- IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5
- IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.