14-3-3 zeta Monoclonal Antibody (C5), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
14-3-3 zeta
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
1110013I11Rik, 14-3-3 delta, 14-3-3 protein zeta/delta, 14-3-3 protein/cytosolic phospholipase A2, 14-3-3 zeta, 1433Z, 14-3-3z, 14-3-3zeta, 14-3-3-zeta, 143Z, AI596267, AL022924, AU020854, epididymis luminal protein 4, epididymis secretory protein Li 3, epididymis secretory protein Li 93, factor activating exoenzyme S, FAS, HEL4, HEL-S-3, HEL-S-93, KCIP-1, mitochondrial import stimulation factor S1 subunit, Msfs1, phospholipase A2, protein kinase C inhibitor protein 1, protein kinase C inhibitor protein-1, SEZ-2, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide, tyrosine 3-monooxygenase tryptophan 5-monooxygenase activation protein, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, YWHAD, YWHAZ
Gene Symbols
Ywhaz
Isotype
IgG2b κ
Purification Method
Protein A/G
Gene
Ywhaz
Clone
C5
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Rat
Gene Accession No.
P63101, P63102, P63104
Gene ID (Entrez)
22631, 25578, 7534
Immunogen
Recombinant Human YWHAz protein, Met1-Asn245 (Accession #P63104)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells
- Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing
- The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins
- By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis
- Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor
- Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.