50-245-285
Myeloperoxidase (MPO) Monoclonal Antibody (MPO455-8E6), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-245-285-Each-of-1 | In Stock | ₹ 32,663.00 |
50-245-285 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,663.00
GST (18%): ₹ 5,879.34
Total Price: ₹ 38,542.34
Antigen
Myeloperoxidase (MPO)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P05164
Gene Symbols
MPO
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4353
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
MPO455-8E6
Conjugate
PE
Gene
MPO
Gene Alias
84 kDa myeloperoxidase; 89 kDa myeloperoxidase; mKIAA4033; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Description: The monoclonal antibody MPO455-8E6 recognizes myeloperoxidase (MPO), a protein within the azurophilic granules of myeloid cells
- MPO is a multimeric protein comprised of two 55 kDa subunits and two 15 kDa subunits
- The larger subunits associate with a heme protein resulting in a greenish color
- As an enzyme, MPO breaks down hydrogen peroxide and oxidizes tyrosine
- The products of this reaction, hypochlorous acid and tyrosyl radical, cause the cytotoxic and killing effects characteristic of neutrophils
- Myeloperoxidase is important in the diagnosis of some cancers and increases in serum levels have been shown to correlate with cardiac events
- Applications Reported: This MPO455-8E6 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This MPO455-8E6 antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells using the Intracellular Fixation & Permeablization Buffer Set (cat
- 88-8824)
- For best results, whole blood should first be stained with antibodies to surface antigens then treated with 1X RBC lysis buffer (cat
- 00-4333) to lyse erythrocytes
- Then, for intracellular staining for MPO, cells should be fixed with IC Fixation Buffer (cat
- 00-8222) washed two times with Permeabilization Buffer (cat
- 00-8333) and then incubated with MPO455-8E6 for 30-60 minutes
- Myeloperoxidase (MPO) is a heme protein that is synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules
- It is produced as a single chain precursor and subsequently cleaved into a light and heavy chain
- The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains
- This enzyme is responsible for producing hypohalous acids that are central to the microbicidal activity of neutrophils
- Diseases that are associated with MPO include Myeloperoxidase Deficiency and Alzheimer's Disease, Familial, 1.