HIF-1 alpha Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™
Mouse Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HIF-1 alpha
Applications
ELISA
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Bovine, Human, Mouse, Rat
Gene Accession No.
O35800, Q16665, Q61221, Q9XTA5
Gene ID (Entrez)
15251, 281814, 29560, 3091
Immunogen
This HIF-1 alpha antibody was raised against a partial protein containing amino acid residues 329-530 of human HIF-1 alpha.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
HIF1A
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
200mM HEPES, 50mM sodium acetate with 100mM NaCl, 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Gene Symbols
HIF1A
Isotype
IgG2a
Purification Method
Metal-chelate chromatography
Product Type
Antibody
Related Products
Description
- HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension
- HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors
- HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia
- Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia
- HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
- Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions
- Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation
- In humans, it is located on the q arm of chromosome 14
- The C-terminal of HIF1A binds to p300
- p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.