HIRA Monoclonal Antibody (WC15), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HIRA
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; Tuple1
Gene Symbols
HIRA
Isotype
IgG
Purification Method
Protein G
Product Type
Antibody
Clone
WC15
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
P54198, Q61666
Gene ID (Entrez)
15260, 7290
Immunogen
This HIRA antibody was raised against a GST-fusion protein containing residues 421-729 of human HIRA.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
HIRA
Related Products
Description
- HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes
- Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin
- It plays an important role in the formation of the senescence-associated heterochromatin foci
- These foci likely mediate the irreversible cell cycle changes that occur in senescent cells
- It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.