TWIST Monoclonal Antibody, Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TWIST
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
P26687, Q15672
Gene ID (Entrez)
22160, 7291
Immunogen
This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
TWIST1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
AA960487; ACS3; B-HLH DNA binding protein; BHLHA38; BOS_4079; BPES2; BPES3; charlie chaplin; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska; Skam10Jus; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; twist homolog 1 (Drosophila); TWIST homolog of drosophila; TWIST1; Twist-related protein 1
Gene Symbols
TWIST1
Isotype
IgG1
Purification Method
Protein G
Product Type
Antibody
Related Products
Description
- TWIST1 acts as a transcriptional regulator
- It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction
- TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B
- TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition
- Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.