7188626
DNMT3B Monoclonal Antibody (2C1), Active Motif™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
DNMT3B
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; DNMT3B; ICF; ICF1; M.HsaIIIB; m.MmuIIIB; MGC1090; MmuIIIB
Gene Symbols
Dnmt3b
Isotype
IgG2b
Purification Method
Protein G
Product Type
Antibody
Clone
2C1
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human
Gene Accession No.
Q9UBC3
Gene ID (Entrez)
1789
Immunogen
This antibody was raised against a peptide corresponding to amino acid residue(s) 383-396 of human DNMT3b.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Dnmt3b
Related Products
Description
- CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation
- Studies in mice have demonstrated that DNA methylation is required for mammalian development
- This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation
- The protein localizes primarily to the nucleus and its expression is developmentally regulated
- Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome
- Six alternatively spliced transcript variants have been described
- The full length sequences of variants 4 and 5 have not been determined.