7188678
HDAC3 Monoclonal Antibody (3G6), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HDAC3
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
AW537363; HD3; Hdac3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; histone deacetylase 3-like protein; RPD3; RPD3-2; SMAP45
Gene Symbols
HDAC3
Isotype
IgG
Purification Method
Protein G
Product Type
Antibody
Clone
3G6
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
O15379
Gene ID (Entrez)
8841
Immunogen
This HDAC3 antibody was raised against a synthetic peptide corresponding to amino acids 411-428 of human HDAC3.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
HDAC3
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Description
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events
- Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA
- HDAC3 belongs to the histone deacetylase/acuc/apha family
- It has histone deacetylase activity and represses transcription when tethered to a promoter
- It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1
- This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis
- This gene is regarded as a potential tumor suppressor gene.