89-126-708

AR (phospho S213), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Manufacturer: Abnova Corporation

Select a Size

Pack Size SKU Availability Price
Each of 1 89-126-708-Each-of-1 In Stock ₹ 87,220.00

89-126-708 - Each of 1

₹ 87,220.00

In Stock

Quantity

1

Base Price: ₹ 87,220.00

GST (18%): ₹ 15,699.60

Total Price: ₹ 1,02,919.60

Antigen

AR

Classification

Polyclonal

Conjugate

Unconjugated

Dilution

Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.

Gene

AR

Gene Symbols

AR

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding S213 of AR.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

Immunohistochemistry (PFA fixed)

Concentration

1 mg/mL

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of AR.

Formulation

In PBS, pH 7.2 (0.05% sodium azide)

Gene Alias

AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM

Host Species

Rabbit

Purification Method

Antigen affinity purification

Regulatory Status

RUO

Gene ID (Entrez)

367

Content And Storage

Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

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Description

  • The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain
  • The protein functions as a steroid-hormone activated transcription factor
  • Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
  • This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein
  • Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease)
  • Mutations in this gene are also associated with complete androgen insensitivity (CAIS)
  • Two alternatively spliced variants encoding distinct isoforms have been described
  • [provided by RefSeq