MilliporeSigma™ phospho Glucocorticoid Receptor (Ser134), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1008MI-Each-of-1 | In Stock | ₹ 40,633.84 |
ABS1008MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
phospho Glucocorticoid Receptor (Ser134)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NR3C1, GCCR, GCR, GCRST, GRL
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
The target phosphorylation site recognized by this polyclonal antibody is present in all 9 human GR spliced isoforms (Ser108 of isoforms Alpha-B and Beta-B; Ser134 of all the other isoforms) and in both rat GR spliced isoforms (Ser155 of isoform A and Ser128 of isoform B) reported by UniProt (P04150 and P06536, respectively).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in Tris-buffered saline (pH 8.0) with 0.05% Sodium Azide.
Gene Accession No.
P04150
Immunogen
Linear peptide corresponding to a human glucocorticoid receptor sequence containing phosphorylated Ser134.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000167
Target Species
Human
Related Products
Description
- Glucocorticoid receptor (UniProt P04150; also known as GR, Nuclear receptor subfamily 3 group C member 1) is encoded by the NR3C1 (also known as GCCR, GCR, GCRST, GRL) gene (Gene ID 2908) in human
- Glucocorticoid receptor is widely expressed in almost all cell types and regulates genes that control development, metabolism, and immune response upon binding glucocorticoids
- Hormone-bound GR translocates from the cytoplasm to the nucleus where it regulates gene transcriptions by binding to glucocorticoid response elements (GREs) or by interacting with various transcription factors
- Alternatively, hormone-bound GR can represses gene transcriptions by blocking the nuclear translocation of transcription factors
- BDNF-stimulated TrkB activation is shown to induce GR phosphorylation at Ser155 and Ser287 in primary rat cortical neurons (equivalent to human GR Ser134 and Ser267), resulting in enhanced GR transcription activity
- GR is composed of an N-terminal modulating domain (a.a
- 1-420), a DNA-binding domain (a.a
- 421-486), and a C-terminal ligand-binding domain (a.a
- 528-777).