BDB551051
Bcl-2 w/control Hamster anti-Human, Unlabeled, Clone: 6C8, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB551051-Each-of-1 | In Stock | ₹ 25,587.50 |
BDB551051 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,587.50
GST (18%): ₹ 4,605.75
Total Price: ₹ 30,193.25
Antigen
Bcl-2 w/control
Classification
Monoclonal
Conjugate
Unconjugated
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG
Applications
Western Blot
Clone
6C8
Host Species
Hamster
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Related Products
Description
- Bcl-2 is considered to be novel among proto-oncogenes because it blocks apoptosis (programmed cell death) in many cell types
- Apoptosis is an active form of cellular suicide that typically requires new RNA and protein synthesis and is associated with distinct morphological changes including cell shrinkage, cytoplasm membrane blebbing, nuclear fragmentation and DNA degradation
- The Bcl-2 gene was first found in t(14:18) containing follicular B-cell lymphomas
- A high proportion of these lymphomas contains t(14:18) chromosomal translocations involving the human Bcl-2 gene
- Translocation of Bcl-2 sequences from chromosome 18 onto the transcriptionally active immunoglobulin locus at chromosome band 14q32 in B-cells deregulates Bcl-2 gene expression, resulting in high levels of Bcl-2 mRNA and protein expression
- Because Bcl-2 blocks apoptosis, it may contribute to tumorigenesis by prolonged cell survival rather than by accelerating the rate of cell proliferation
- The reduced molecular weight of Bcl-2 is 26 kDa
- Additional minor bands at 27-31 kDa and 18-21 kDa may also be observed.