Factor XIII A Recombinant Rabbit Monoclonal Antibody (PD00-08), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550689-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550689 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
Factor XIII A
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P00488
Gene Symbols
F13A1
Immunogen
Synthetic peptide within Human Factor XIIIa aa 550-732/732 (C terminal).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
PD00-08
Conjugate
Unconjugated
Gene
F13A1
Gene Alias
1200014I03Rik, AI462306, bA525O21.1 (coagulation factor XIII, A1 polypeptide), coagulation factor XIII A chain, coagulation factor XIII, A polypeptide, coagulation factor XIII, A1 polypeptide, coagulation factor XIII, A1 subunit, coagulation factor XIII, alpha subunit, coagulation factor XIIIa, F13A, F13a1, factor viiia, Factor XIIIA, fibrin stabilizing factor, A subunit, fibrinoligase, FSF, A subunit, protein-glutamine gamma-glutamyltransferase A chain, RP11-232H4.1, TGase, transglutaminase A chain, transglutaminase. plasma
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2162
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: Human placenta tissue lysates, human lymph nodes tissue, human placenta tissue
- Predicted band size: 83 kDa Subcellular Location: Secreted, Cytoplasm
- This gene encodes the coagulation factor XIII A subunit
- Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade
- Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits
- The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules
- Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin
- Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII
- This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
- It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin
- Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone
- These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.