GCAP1 Monoclonal Antibody (G2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1724-Each-of-1 | In Stock | ₹ 40,940.00 |
MA1724 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,940.00
GST (18%): ₹ 7,369.20
Total Price: ₹ 48,309.20
Antigen
GCAP1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P43080, P46065
Gene Symbols
Guca1a
Immunogen
Bacterial expressed full length GCAP-1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Non-human Primate
Product Type
Antibody
Isotype
IgG2a
Applications
Western Blot
Clone
G2
Conjugate
Unconjugated
Gene
Guca1a
Gene Alias
C6orf131; COD3; cone dystrophy 3; CORD14; GC-A; GCAP; GCAP 1; GCAP1; Guanylate cyclase activator 1A; guanylate cyclase activator 1a (retina); guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; guanylyl cyclase-activating protein; guanylyl cyclase-activating protein 1; GUCA; GUCA1; GUCA1A; mGCAP1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
282243, 2978
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-724 detects GCAP-1 from human, non-human primate and bovine samples
- This antibody is specific for GCAP-1 and does not react with other isotypes
- MA1-724 has been successfully used in Western blot procedures
- By Western blot, this antibody detects a ∽23 kDa protein representing GCAP-1 protein on bovine rod outer segment membranes
- The MA1-724 immunogen is bacterial expressed full length GCAP-1
- Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors
- The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites
- The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina
- In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified
- Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy
- The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein
- However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.