RASA1 Monoclonal Antibody (B4F8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA4001-Each-of-1 | In Stock | ₹ 50,018.00 |
MA4001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,018.00
GST (18%): ₹ 9,003.24
Total Price: ₹ 59,021.24
Antigen
RASA1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P09851, P20936, P50904
Gene Symbols
RASA1
Immunogen
Full length recombinant human GAP.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
B4F8
Conjugate
Unconjugated
Gene
RASA1
Gene Alias
CMAVM; CM-AVM; Gap; GAPX; GTPase-activating protein; p120; p120 RAS GTPase activating protein; p120GAP; p120RASGAP; p120-rasGAP; PKWS; Ras GTPase-activating protein 1; ras GTPase-activating protein 1-like protein; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein RAS p21); RAS p21 protein activator (GTPase activating protein) 1; RAS p21 protein activator 1; Rasa; RASA1; RASGAP; triphosphatase-activating protein; unnamed protein product
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
218397, 25676, 282032, 5921
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Related Products
Description
- MA4-001 detects GTPase activating protein (GAP) from human, mouse, rat, bovine and non-human primate tissues
- MA4-001 has been successfully used in Western blot, immunofluorescence and immunoprecipitation procedures
- By Western blot, this antibody recognizes a single 120 kDa protein representing ras GAP from RS-2 cell lysate
- Immunofluorescence staining of GAP in mouse fibroblast cells with MA4-001 results in diffuse cytoplasmic staining
- Following the addition of PDGF, immunofluorescence staining shows that some GAP rapidly translocates to the plasma membrane
- MA4-001 immunoprecipitates GAP that is complexed with the GAP related p190
- The MA4-001 antigen is full length recombinant human GAP
- Epitope mapping studies suggest that this antibody binds a portion of GAP that contains the src homology regions SH2 & SH3
- Reconstitute with PBS
- TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples
- The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors
- TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10
- Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation
- Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC
- It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.