MAB1620AF55
MilliporeSigma™ Mouse anti-Cytokeratin 5,6, Clone: D5/16B4, Alexa Fluor 555,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB1620AF55-Each-of-1 | In Stock | ₹ 48,229.10 |
MAB1620AF55 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,229.10
GST (18%): ₹ 8,681.238
Total Price: ₹ 56,910.338
Antigen
Cytokeratin 5,6
Classification
Monoclonal
Conjugate
Alexa Fluor 555
Gene Accession No.
P13647
Host Species
Mouse
Purification Method
Protein A Purfied
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Applications
Immunocytochemistry
Clone
D5/16B4
Formulation
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Symbols
KRT5; DDD1; DM-EBS; EBSMCE; K-EBS; MP-EBS; WC-EBS
Immunogen
Purified human cytokeratin 5 (Mischke, D., and Wild, G.A. (1987). J. Invest. Dermatol. 88(2):191-197; Wild, G.A., and Mischke, D. (1986). Exp. Cell Res. 162(1):114-126).
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NM_000424.3
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1
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Description
- Specifically detects Cytokeratin 5,6 clone: D5/16B4 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry Keratin, type II cytoskeletal 5 (UniProt P13647; also known as 58kDa cytokeratin, CK-5, Cytokeratin-5, K5, Keratin-5, Type-II keratin Kb5) is encoded by the KRT5 (also known as DDD1, DM-EBS, EBSMCE, K-EBS, MP-EBS, WC-EBS) gene (Gene ID 3852) in human
- Cytokeratin-5 (Keratin-5 or K5) belongs to a family of highly conserved epithelial-specific intermediate filament (IF) proteins
- Each epithelium is characterized by its unique keratin expression pattern
- In interfollicular epidermis, four major keratins are synthesized and co-polymerize in pairs, K5/K14 and K1/KI0, to form filaments
- The expression of these two pairs is strictly regulated during normal keratinocyte differentiation
- The K5/K14 filament is expressed in proliferating basal cells, while the K1/K10 filament is expressed during the transition to terminal differentiation and at the cessation of cell division
- Similar to other IF members, Keratin-5 contains a central rod region composed of alpha helix segments (a.a
- 168-203, 223-315, 339-477) that allow two different IF proteins, one type I (acidic) and one type II (basic) keratin, to intertwine into a coiled-coil formation via hydrophobic interaction
- Kearain-5 is a type II keratin that pairs with the type I keratin-14 to form IF.