MilliporeSigma™ MNDA, Rat, Unlabeled, Clone: 3C1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC1170MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABC1170MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
MNDA
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P41218
Immunogen
Human peripheral blood granulocyte nuclei.
Quantity
100 μg
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_002423
Target Species
Human
Form
Purified
Applications
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
3C1
Conjugate
Unconjugated
Gene
MNDA
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3C1 reacted with both denatured and non-denatured MNDA. Clone 3C1 reacted with nuclear extract from NMDA-expressing HL-60, but not non-MNDA-expressing BII, human myeloid leukemia cells (Hudson, C.R., et al. (1988). Hybridoma. 7(6):541-553).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Myeloid cell nuclear differentiation antigen (UniProt P41218) is encoded by the MNDA gene (Gene ID 4332) in human
- MNDA is a member of the interferon-inducible p200 (IFI-200) family of proteins with a conserved HIN-200 domain (human MNDA a.a
- 196-394) that mediate interaction with proteins and DNA
- IFI-200 members possess antimicrobial, cell growth regulatory, differential regulatory and immunomodulatory properties
- In bone marrow-derived- and mature neutrophils, MNDA is predominantly located in the nucleus
- MNDA is cleaved by caspases in neutrophils undergoing apoptosis and relocated to the cytoplasm
- MNDA is downregulated in myelodysplastic syndrome and completely absent in a mouse strain susceptible to B-cell plasmacytoma, while being markedly (1,000-fold) upregulated in a mouse strain resistant to B-cell plasmacytoma
- Originally thought to be restricted to, myeloid cells, MNDA and other IFI-200 family members are also found to be expressed in a variety of non-myeloid cell types
- MNDA is highly expressed in normal bone tissue, while being at markedly low levels in osteosarcoma cells
- MNDA overexpression is shown to induce apoptosis, inhibit proliferation, and reduce the migration of osteosarcoma cells.