MilliporeSigma™ FBXO15, Mouse, Unlabeled, Clone: 3B11.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABD127MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABD127MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
FBXO15
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgMκ antibody in buffer containing PBS with 0.05% Sodium Azide.
Gene Accession No.
Q8NCQ5
Immunogen
KLH-conjugated linear peptide corresponding an N-terminal sequence of human FBXO15.
Quantity
200 μL
Research Discipline
Stem Cell Research
Gene ID (Entrez)
NP_001136430
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
3B11.1
Conjugate
Unconjugated
Gene
FBXO15, FBX15
Host Species
Mouse
Purification Method
Purified by Ion-Exchange Chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3B11.1 recoginzes an N-terminal epitope present in spliced isoform 1 (UniProt Q8NCQ5-1), but absent in spliced isoform 2 (UniProt Q8NCQ5-2).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgM κ
Related Products
Description
- F-box only protein 15 (UniProt Q8NCQ5) is encoded by the FBXO15 (also known as FBX15) gene (Gene ID 201456) in human
- Polyubiquitination of proteins is mediated by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s)
- There exist RING finger-type, HECT-type, U-box-type, and PHD-finger-type E3 ligases
- The RING finger-type E3s include seven cullin-based E3s, such as SKP1–CUL1–F-box-protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C)
- F-box proteins use their N-terminal F-box motif to bind Skp1 and other motif(s) in their C-terminal region for substrates recognition and recruitment
- F-box proteins are divided into the FBXW subclass that contains WD40 repeat domains, the FBXL subclass that contains leucine-rich repeat domains, and the F-box only (FBXO) subclass that contains not yet fully characterized substrate recognition domains
- SCF-Fbxo15 is reported to mediate the ubiquitination of cardiolipin synthase (CLS1) for proteasomal degradation in human lung epithelial cells
- PTEN-induced putative kinase 1 (PINK1) is shown to phosphorylate CLS1 and cause its release from the inner mitochondrial membrane to the outer membrane, making it accessible for Fbxo15-targeted ubiquitination.