MilliporeSigma™ CTIP2/BCL11B, Rat, Unlabeled, Clone: 25B6,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1045MI-Each-of-1 | In Stock | ₹ 43,318.08 |
MABE1045MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,318.08
GST (18%): ₹ 7,797.254
Total Price: ₹ 51,115.334
Antigen
CTIP2/BCL11B
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat monoclonal antibody IgG2a in buffer containing 150mM NaCl, 15mM HEPES, pH 7.5, with 0.02% Sodium Azide.
Gene Accession No.
Q99PV8
Immunogen
GST-tagged recombinant full-length mouse CTIP2 Beta isoform (Senawong, T., et al. (2003). J. Biol. Chem. 278(44):43041-43050).
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_067374
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
25B6
Conjugate
Unconjugated
Gene
Bcl11b, Ctip2, Rit1
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 25B6 recognizes both the Alpha and Beta spliced isoforms of human and mouse CTIP2/BCL11B.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a
Related Products
Description
- B-cell lymphoma/leukemia 11B (UniProt Q99PV8; also known as B-cell CLL/lymphoma 11B, BCL-11B, COUP-TF-interacting protein 2, mRit1, Radiation-induced tumor suppressor gene 1 protein) is encoded by the Bcl11b (also known as Ctip2, Rit1) gene (Gene ID 58208) in murine species
- CTIP2/CBL11B is a C2H2 zinc finger protein that binds GC-rich response elements and is reported to associate with a variety of cofactors, including the corepressor complexes NuRD, Sirt1, histone acetyltransferase (HAT) p300, functioning both as a transcriptional repressor and activator
- CTIP2/CBL11B is required at multiple developmental checkpoints for T cell commitment and maintenance
- CTIP2/CBL11B expression is initiated at double-negative 2 (DN2) stage of T cell development and is maintained in mature T lymphocytes, with lower levels found in NK cells, but not in B cells, myeloid or dendritic cells
- Bcl11b-/- mice die shortly after birth due to a blockade of thymocyte development at the DN2 stage
- Bcl11b-deficient DN2 thymocytes are highly proliferative and retain the potential to differentiate into NK cells and myeloid lineages, but not mature T-cells.