MilliporeSigma™ Tankyrase-2, Mouse, Unlabeled, Clone: 2F5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1025MI-Each-of-1 | In Stock | ₹ 37,706.63 |
MABE1025MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,706.63
GST (18%): ₹ 6,787.193
Total Price: ₹ 44,493.823
Antigen
Tankyrase-2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9H2K2
Immunogen
GST-tagged recombinant human Tankyrase-2 fragment from the region between ANK repeats 6 & 8.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_079511
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
2F5.1
Conjugate
Unconjugated
Gene
TNKS2, PARP5B, TANK2, TNKL
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 2F5.1 recognizes an epitope in the region between ANK repeats 6 & 8 of human Tanyrase-2.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Tankyrase-2 (EC 2.4.2.30; UniProt Q9H2K2; also known as ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, PARP-5B, Poly [ADP-ribose] polymerase 5B, TANK2, TNKS-2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, TRF1-interacting ankyrin-related ADP-ribose polymerase 2) is encoded by the TNKS2 (also known as PARP5B, TANK2, TNKL) gene (Gene ID 80351) in human
- Tankyrase-2 belongs to the poly(ADP-ribosylation) polymerase (PARP) family of enzymes that mediate post-translational modification of proteins by poly(ADP-ribosyl)ation, where repeating units of ADP-ribose linked by glycosidic bonds were added to aspartate, glutamate, asparagine, arginine or lysine residues of substrate proteins
- Poly(ADP-ribose) (PAR) modification is reversible through the action of poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl protein lyase
- Tankyrase-2 and the related Tankyrase-1 share a common domain organization with 15 N-terminal ankyrin-repeats (a.a
- 57-776 in TNKS2) involved in substrate recognition, a sterile alpha motif (SAM) domain (a.a
- 873-936 in TNKS2) required for dimerization, followed by the C-terminal PARP domain (a.a
- 959-1164 in TNKS2)
- Mice with either Tnks1- or Tnks2-knockout are viable, while double Tnks1-/Tnks2-knockout is lethal at embryonic day 9.5, suggesting a functional redundancy between these two enzymes
- Both tankyrases target and suppress Axin2, a well known β-catenin negative regulator
- Tankyrase-2 ribosylates Src-binding adapter protein 3BP2, leading to its ubiquitination and proteasomal degradation in macrophages and osteoclasts
- Loss of tankyrase-mediated 3BP2 negative regulation underlies the pathogenic mechanism of cherubism, an autosomal dominant disorder affecting cranial bone development.