MABE340AF55
MilliporeSigma™ MDM2, Mouse, Alexa Fluor 555, Clone: IF2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE340AF55-Each-of-1 | In Stock | ₹ 46,799.76 |
MABE340AF55 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,799.76
GST (18%): ₹ 8,423.957
Total Price: ₹ 55,223.717
Antigen
MDM2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2b antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % Sodium Azide.
Gene Accession No.
Q00987
Immunogen
Recombinant human MDM2.
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_002383
Target Species
Human
Form
Purified
Applications
Immunocytochemistry
Clone
IF2
Conjugate
Alexa Fluor 555
Gene
MDM2
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone IF2 recognizes the ∽85/90 kDa (apparent MW) MDM2, as well as isoforms of ∽57/60 kDa and ∽74/76 kDa by immunoblotting using the unconjugated antibody (Cat. Nos. MABE340 & OP46).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b
Related Products
Description
- E3 ubiquitin-protein ligase Mdm2 (UniProt Q00987; also known as Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2) is encoded by the MDM2 gene (Gene ID 4193) in human
- MDM2 is an E3 ubiquitin ligase that is most widely studied for its role in regulating the p53 tumor suppressor
- MDM2 antagonizes p53 transcriptional activity by binding to and blocking p53 N-terminal trans-activation domain
- MDM2 can also monoubiquitinate p53, thereby promoting p53 cytoplasmic localization to prevent p53 nuclear funtion
- In addition, MDM2, when in complex with p300, also mediates p53 polyubiquitination, resulting in p53 proteosomal degradation
- MDM2 overexpression is shown to inhibit DNA double-strand break repair mediated through its interaction with Nbs1 in a p53-independent manner.