MABT528MI
MilliporeSigma™ Connexin 43, CT, Mouse, Unlabeled, Clone: 1C5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT528MI-Each-of-1 | In Stock | ₹ 50,816.33 |
MABT528MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,816.33
GST (18%): ₹ 9,146.939
Total Price: ₹ 59,963.269
Antigen
Connexin 43, CT
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P17302
Immunogen
GST-tagged recombinant human connexin 43 C-terminal cytoplasmic tail fragment.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_000156
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1C5.1
Conjugate
Unconjugated
Gene
GJA1, AVSD3, CMDR, GJAL, HSS, ODDD
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1C5.1 targets an epitope within the second half of the C-terminal cytoplasmic tail.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Gap junction alpha-1 protein (UniProt P17302; also known as Connexin-43, Cx43, Gap junction 43kDa heart protein) is encoded by the GJA1 (also known as AVSD3, CMDR, GJAL, HSS, ODDD) gene (Gene ID 2697) in human
- A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell
- Connexin-43 is a polytopic integral membrane protein oligomerizes into a hexamer or connexon
- It is he most ubiquitously expressed connexin and contains a long C-terminal tail, an N-terminal domain, and multiple transmembrane domains
- The C-terminal tail domain of human connexin-43 contains 50 amino acids and includes post-translational modification sites, as well as binding sites for transcription factors, cytoskeleton elements, and other proteins
- The C-terminal tail regulates pH gating and channel assembly, whereas the N-terminal domain is involved in channel gating and oligomerization and controls the switch between channel open and closed states
- Mutations in connexin-43 result in multiple disorders, such as oculodentodigital dysplasia that is characterized by microcornea, microphthalmia, and syndactyly of the fourth and fifth fingers
- Connexin-43 is shown to negatively regulate growth of colon cancer cells, in part by enhancing apoptosis
- Loss of connexin-43 expression in colorectal cancers is correlated with significantly shorter relapse-free and overall survival.