MilliporeSigma™ anti-Neurophysin 2/NP-AVP Clone: PS 41,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN845MI-Each-of-1 | In Stock | ₹ 47,205.60 |
MABN845MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,205.60
GST (18%): ₹ 8,497.008
Total Price: ₹ 55,702.608
Antigen
Neurophysin 2/NP-AVP
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P01186
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone PS 41 reacts with Vasopressin-neurophysin 2-copeptin precursor, neurophysin 2, but not Arg-vasopressin, copeptin, oxytocin, or neurophysin 1.
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2b κ
Applications
Immunoassay, ELISA, Immunohistochemistry, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
Clone
PS 41
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Avp
Immunogen
KLH-conjugated acid soluble extract of rat (Sprague-Dawley) intermediate lobes.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_058688
Target Species
Rat
Form
Purified
Related Products
Description
- Specifically detects Neurophysin 2/NP-AVP Clone: PS 41 in Rat samples, and it is validated for Electron Microscopy, ELISA, Immunohistochemistry, Immunoprecipitation, Radioimmunoassay, Western Blotting The neurophysin 1 and 2 (NPI and NPII) are carriers of peptide hormone oxytocin (OT) and vasopressin (AVP), respectively
- Each NP and its associated hormone peptide are synthesized as one precursor protein, OT-NPI (UniProt P01179) encoded by the Oxt (or Ot) gene or AVP-NPII (UniProt P01186) encoded by the Avp gene in rat species
- Post-translational cleavages remove the signal peptide and process the precursor into mature OT and NPI (aa 20-28 and aa 32-135, respectively, of OT-NPI) or AVP and NPII (aa 24-32 and aa 36-128, respectively, of AVP-NPII)
- OT is a potent hormone and neurotransmitter secreted within the pituitary gland
- OT exerts its biological activity through its receptor OXTR (also known as OTR)
- OT is used clinically for labor induction and may exhibit therapeutic potential for treating social anxiety disorders
- AVP functions primarily as an anti-diuretic and regulates the concentration of water, glucose, and salts in blood
- AVP is secreted from the posterior pituitary, but exerts its biological activity in the kidney via the G protein-coupled receptor AVPR2 (V2R).