MilliporeSigma™ Periostin, Mouse, Unlabeled, Clone: 5B2.3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1183MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABS1183MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Periostin
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q15063
Immunogen
GST-tagged recombinant human periostin C-terminal fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_006466
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
5B2.3
Conjugate
Unconjugated
Gene
POSTN, OSF2
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 5B2.3 epitope lies within a region C-terminal to the FAS1 domains. Immunogen covered region is 100% present in isoforms 1 (OSF-2OS), 2 (OSF-2p1), and 5, but partially missing in spliced isoforms 3, 4 (PDL-POSTN), 6, and 7. Clone 5B2.3 immunoreactivity toward these latter isoforms is possible, but has not been confirmed.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Periostin (UniProt Q15063; also known as OSF-2, Osteoblast-specific factor 2, PN) is encoded by the POSTN (also known as PSF2) gene (Gene ID 10631) in human
- Periostin is an extracellular matrix (ECM) protein predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL)
- Periostin plays an essential role in the process of remodeling during tissue/organ development/repair and inflammation
- Periostin derived from fibroblasts is shown to induce keratinocytes differentiation and proliferation
- Periostin is a mediator for epidermal hyperplasia and is highly expressed in the dermis of both atopic dermatitis (AD) and psoriasis patients
- Periostin level is also reported to be upregulated in patients with acute or chronic hepatitis and correlates well with serum TGF- 1 and TGF- 2 levels
- The PDL-POSTN spliced isoform is predominantly expressed in PDL, it binds integrin v 3 with a higher affinity and induces strong activation of the integrin v 3-focal adhesion kinase (FAK) signaling pathway
- Periostin is produced with a signal peptide (a.a
- 1-21), the removal of which yields the mature protein with an N-terminal cysteine-rich EMI (a.a
- 40-94) domain and four asciclin I or FAS1 domains (a.a
- 97-230, 234-365, 368-492, 496-628)
- Alternative splicing generate several C-terminal domain variants with tissue-specific expression patterns.