MABS1293
MilliporeSigma™ ING5, Rat, Unlabeled, Clone: 7A11,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1293-Each-of-1 | In Stock | ₹ 41,813.98 |
MABS1293 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
ING5
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q8WYH8
Immunogen
GST-tagged recombinant human ING5 (Linzen, U., et al. (2015). PLoS One. 10(4):e0123736).
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_115705
Target Species
Human
Form
Purified
Applications
Immunoprecipitation, Western Blot
Clone
7A11
Conjugate
Unconjugated
Gene
ING5
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 7A11 detected shRNA-mediated ING5 downregulation in HEK293 cells (Linzen, U., et al. (2015). PLoS One. 10(4):e0123736).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Inhibitor of growth protein 5 (UniProt Q8WYH8; also known as p28ING5) is encoded by the ING5 gene (Gene ID 84289) in human
- ING5 is a member of the ING family of proteins known for their antiporliferation activity
- ING proteins bind to methylated core histones through their PHD motif (a.a
- 186-235 in ING5), and ING5 is known to target histone H3 on di- or trimethylated Lys4 (H3K4me2/3)
- ING5 associates with two histone acetylase (HAT) complexes, HBO1 and nucleosomal H3-specific MOZ/MORF, that interact with the MCM helicase and are essential for DNA replication during S phase
- ING5 deregulations are reported in various cancers and ING5 located chromosome region is deleted in oral squamous cell carcinoma and odontogenic tumors
- In addition, ING5 cytosolic localization is reported in some head and neck squamous cell carcinoma tumors and the cytosolic localization positively correlates with the progression of gastric cancer
- ING5 also pormotes p53-dependent gene transcription by enhancing p53 acetylation in a p300-dependent manner
- ING5 is shown to interact with p63 that mediates the self-renewal of epidermal stem cells, and ING5 knockdown causes differentiation of epidermal stem cells
- Similar to other ING proteins, ING5 possesses a PHD (plant homeodomain) type zinc finger, an NCR (novel conserved region), a LZL (leucine zipper like) finger, and two NLS (nuclear localization sequence) motifs.