MABS1281
MilliporeSigma™ Itk, Mouse, Unlabeled, Clone: 2F12,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1281-Each-of-1 | In Stock | ₹ 44,937.88 |
MABS1281 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,937.88
GST (18%): ₹ 8,088.818
Total Price: ₹ 53,026.698
Antigen
Itk
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q08881
Immunogen
GST-tagged recombinant human/mouse/rat Itk N-terminal fragment.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_005537
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
2F12
Conjugate
Unconjugated
Gene
ITK, EMT, LPFS1, LYK
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 2F12 targets the N-terminal region of human, mouse, and rat Itk.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Dual specificity protein phosphatase 6 (EC 3.1.3.16; EC 3.1.3.48; UniProt Q16828; also known as Dual specificity protein phosphatase PYST1, MAP kinase phosphatase 3, Mitogen-activated protein kinase phosphatase 3, MKP-3) is encoded by the DUSP6 (also known as HH19, MKP3, PYST1) gene (Gene ID 1848) in human
- MPK-3 (DUSP6) belongs to the family of dual-specificity phosphatases (DUSPs) that mediate dephosphorylation of MAPKs on threonine/serine and tyrosine residues
- DUSP6 is upregulated in HER2+ carcinomas and is among several DUSPs thought to be involved in breast cancer metastasis
- DUSP1, DUSP4, and DUSP6 are induced during epithelial-to-mesenchymal transition (EMT) and are involved in forming and maintaining breast cancer stem cells (CSCs), DUSP1 knockdown reduces CSC formation, while DUSP4 or DUSP6 knockdown enhances CSC formation
- PKC CK2alpha is reported to phosphorylate DUSP6 and increase its dephosphatase activity
- ERK1/2, on the other hand, can phosphorylate DUSP6 to promote its proteosomal degradation.