MABS1212MI
MilliporeSigma™ Geminin, Mouse, Unlabeled, Clone: 4B10.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1212MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABS1212MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Geminin
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O75496
Immunogen
GST-tagged recombinant human geminin internal fragment.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_001238918
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
4B10.1
Conjugate
Unconjugated
Gene
GMNN
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4B10.1 detects human geminin by targeting an internal epitope.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Geminin (UniProt O75496) is encoded by the GMNN gene (Gene ID 51053) in human
- Geminin is a negative regulator of DNA-replication and the founding member of the Geminin family, whose members also include Idas (multicilin; McIdas) and GemC1 (Geminin coiled-coil domain-containing protein 1)
- Geminin binds Cdt1 and inhibits the mini-chromosome maintenance complex (MCM) loading onto chromatin and pre-replication complex (preRC) formation
- Geminin is a 209-amino acid protein that can form homodimer or heterodimers with either Idas or GemC1 via the middle coiled coil structure (a.a
- 94-144 of Geminin) in a head-to-tail fashion
- The same region in Geminin (a.a
- 82-161) is also essential for Cdt1 interaction
- A homeodomain-binding domain is located at the C-terminal region of Geminin (a.a
- 170-190)
- GemC1 is also implicated in DNA replication but at a later stage than Geminin
- All three Geminin family members play important roles in cell proliferation and differentiation.