MilliporeSigma™ SUN2, Mouse, Unlabeled, Clone: 3.1E,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT880MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABT880MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
SUN2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9UH99
Immunogen
GST-tagged recombinant human SUN2 N-terminal LMNA-binding region fragment.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_001186509.1
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
3.1E
Conjugate
Unconjugated
Gene
SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Target specificity of clone 3.1E was verified by immunocytochemistry and Western blotting analyses using fibroblasts and heart tissue samples from Sun2-knockout mice.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- SUN domain-containing protein 2 (UniProt Q9UH99; also known as Protein unc-84 homolog B, Rab5-interacting protein, Rab5IP, Sad1/unc-84 protein-like 2) is encoded by the SUN2 (also known as FRIGG, KIAA0668, RAB5IP, UNC84B) gene (Gene ID 25777) in human
- It is a single-pass nuclear envelope transmembrane protein that is highly expressed in heart, lung, and muscle
- It has a predicted transmembrane domain and a C-terminal region with similarity to the S
- pombe spindle pole body protein Sad1
- It may also facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage
- It anchors chromosome movement in the prophase of meiosis and is required for telomere attachment to nuclear envelope and gametogenesis
- SUN2 protein may also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5
- Slight overexpression of SUN2 protein is seen in heart tissues form patients with congenital heart defects.