PCSK2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1058-Each-of-1 | In Stock | ₹ 46,146.50 |
PA1058 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,146.50
GST (18%): ₹ 8,306.37
Total Price: ₹ 54,452.87
Antigen
PCSK2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Pcsk2
Gene Alias
6330411F23Rik; AI839700; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; NEC2; Nec-2; Neuroendocrine convertase 2; PC2; PC2-like protein; PCSK2; Phpp-2; Prohormone convertase 2; prohormone convertase 2-like protein; propotein convetase subtilisin/kesin type 2; proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; proprotein convertase type 2; Rpc2; SPC2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18549, 5126
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P16519, P21661
Gene Symbols
Pcsk2
Immunogen
Synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-058 detects prohormone convertase 2 (PC2) from human and mouse alpha pancreas cells
- PA1-058 has been successfully used in ICC/IF and Western blot procedures
- By Western blot, this antibody detects an ∽65 kDa protein representing PC2 from alpha TC 6 cell extract
- This antibody is not recommended for Neuro-2a cells in immunfluorescent applications
- The PA1-058 immunogen is a synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2
- This sequence is completely conserved between mouse and rat protein
- PA1-058 synthetic peptide (PEP-138) is available for use in neutralization and control experiments
- The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors
- Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs
- PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence
- These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment
- The subcellular localization of PC family members varies
- Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.