Progerin Monoclonal Antibody (13A4D4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA518073-Each-of-1 | In Stock | ₹ 59,452.00 |
PIMA518073 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,452.00
GST (18%): ₹ 10,701.36
Total Price: ₹ 70,153.36
Antigen
Progerin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
P02545
Gene Symbols
LMNA
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 604-611 (GAQSPQNC) at the C terminus of Human Progerin
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
13A4D4
Conjugate
Unconjugated
Gene
LMNA
Gene Alias
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
4000
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody specifically recognizes Progerin (Lamin A delta50) and does not cross-react with endogenous prelamin A
- Western blot results show a band at approximately 70 kDa
- Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome
- Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C
- This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein
- Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.