Rb Recombinant Rabbit Monoclonal Antibody (SY63-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532103-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532103 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Rb
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P06400, P13405, P33568
Gene Symbols
RB1
Immunogen
Recombinant protein within mouse Rb aa 682-921
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SY63-03
Conjugate
Unconjugated
Gene
RB1
Gene Alias
Cleaved Rb, delta RB-p70, DRb-p70, exon 17 tumor GOS561 substitution mutation causes premature stop, GOS563 exon 17 substitution mutation causes premature stop, OSRC, p104, p104 chicken Rb, P105RB, p105-Rb, Phospho-Retinoblastoma, pp105, pp110, PPP1R130, pRb, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, rb, RB transcriptional corepressor 1, RB1, Rb-1, Rb-p70, Retin, Retinoblastoma, retinoblastoma 1, retinoblastoma 1 (including osteosarcoma), retinoblastoma 1 protein, retinoblastoma gene, retinoblastoma isoform A, retinoblastoma protein, retinoblastoma suspectibility protein, retinoblastoma tumor suppressor, retinoblastoma-associated protein
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19645, 24708, 5925
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA
- It is phosphorylated on serine and threonine, but not on tyrosine residues
- It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E
- Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth
- Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.