p27 Kip1 Recombinant Rabbit Monoclonal Antibody (SU37-04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532132-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532132 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
p27 Kip1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P46527
Gene Symbols
Cdkn1b
Immunogen
Synthetic peptide within Human p27 KIP 1 aa 149-198
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SU37-04
Conjugate
Unconjugated
Gene
Cdkn1b
Gene Alias
AA408329, AI843786, Cdki1b, CDKN1B, CDKN4, CDN1B, cyclin dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor 1B (p27 Kip1), Cyclin-dependent kinase inhibitor 1B (p27, Kip1), cyclin-dependent kinase inhibitor p27, Cyclin-dependent kinase inhibitor p27 Kip1, cyclin-dependent kinase inhibitor p27/Kip1, KIP1, MEN1B, MEN4, p27, P27 CDKN1B, p27(KIP1), p27Kip1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1027, 83571
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest
- p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes
- p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation
- p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry
- p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.