Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532207-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532207 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
Phospho-TrkB (Tyr817)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P15209, Q16620, Q63604
Gene Symbols
Ntrk2
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Tyr817 of Human TrkB aa 789-822
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SC0556
Conjugate
Unconjugated
Gene
Ntrk2
Gene Alias
AI848316, BDNF/NT-3 growth factors receptor, BDNF-tropomyosine receptor kinase B, C030027L06Rik, EC 2.7.10.1, GP145 TrkB, GP145TrkB, GP145-TrkB, GP145-TrkB/GP95-TrkB, GP95 TrkB, GP95-TrkB, hyperphagia, kinase TrkB, neural receptor protein-tyrosine kinase (trkB), neurotrophic receptor tyrosine kinase 2, neurotrophic tyrosine kinase receptor type 2, neurotrophic tyrosine kinase, receptor, type 2, neurotrophic tyrosine receptor kinase type 2, NTRK 2, Ntrk2, OTTHUMP00000021573, OTTHUMP00000021574, OTTHUMP00000021576, OTTHUMP00000021577, RATTRKB1, Tkrb, Trk B, TRKB, trk-B, trkB protein, trkB tyrosine kinase, TRKB1, Tropomyosin-related kinase B, tyrosine kinase receptor B
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18212, 25054, 4915
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system
- NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF)
- Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses
- TrkB is involved in the development and maintenance of the nervous system
- Moreover, Trk B is a tyrosine kinase gene highly related to Trk A
- Trk B expression is confined to tissues within the central and peripheral nervous systems
- The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3
- TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway
- Signaling through TrkB leads to cell differentiation
- Mutations in the TrkB gene have been associated with obesity and mood disorders
- Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.