ATG5 Recombinant Rabbit Monoclonal Antibody (SN73-07), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532289-Each-of-1 | In Stock | ₹ 48,816.50 |
PIMA532289 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,816.50
GST (18%): ₹ 8,786.97
Total Price: ₹ 57,603.47
Antigen
ATG5
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q3MQ06, Q99J83, Q9H1Y0
Gene Symbols
Atg5
Immunogen
Synthetic peptide within Human ATG5 aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN73-07
Conjugate
Unconjugated
Gene
Atg5
Gene Alias
2010107M05Rik, 3110067M24Rik, APG 5, APG5, APG5 autophagy 5 like (APG5L), APG5 autophagy 5-like protein, APG5 autophagy 5-like protein, isoform 1, APG5L, APG5-LIKE, apoptosis-specific protein, Apoptosis-specific protein (ASP), ASP, atg5, Atg-5, ATG5 autophagy related 5 homolog, ATG5 autophagy related 5 homolog (S. cerevisiae), atg5.L, Atg5l, Atg5-PA, autophagy 5-like protein, autophagy protein 5, autophagy related 5, autophagy related 5 L homeolog, autophagy related 5-like protein, Autophagy-related 5, autophagy-specific gene 5, AW319544, C88337, CG1643, CG1643-PA, DmAtg5, Dmel\CG1643, Dmel_CG1643, hAPG5, hypothetical protein LOC532686, LD34980p, Paddy, XELAEV_18027227mg, zgc:100934
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
11793, 365601, 9474
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process
- ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation
- Following conjugation to ATG12, the conjugate participates in the formation of autophagosome
- ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD)
- The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed
- APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton
- Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity
- The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells
- Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.