TAB1 Monoclonal Antibody (2G4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532953-Each-of-1 | In Stock | ₹ 50,596.50 |
PIMA532953 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
TAB1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
0.01M TBS with 1% BSA, 50% glycerol and 0.03% ProClin 300, pH 7.4
Gene Accession No.
Q15750
Gene Symbols
TAB1
Immunogen
Synthetic peptide, corresponding to the N-terminus of Human TAB1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
2G4
Conjugate
Unconjugated
Gene
TAB1
Gene Alias
2310012M03Rik, 3'-Tab1, b2b449Clo, beta activated kinase-1 binding protein-1, MAP3K7IP1, MGC57664, mitogen activated protein kinase kinase kinase 7 interacting protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1, mitogen-activated protein kinase kinase kinase 7-interacting protein 1, RP3-407F17.2, TAB1, TAB1beta, TAK1-binding protein 1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, TGF-beta-activated kinase 1-binding protein 1, transforming growth factor beta-activated kinase-binding protein 1
Host Species
Mouse
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10454
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1
- TAB1 interacts and thus activates TAK1 kinase
- It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1
- It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.