NFkB p50/p105 Recombinant Rabbit Monoclonal Antibody (RM299), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533067-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA533067 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
NFkB p50/p105
Classification
Recombinant Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P19838
Gene Symbols
NFKB1
Immunogen
A peptide corresponding to residues in the human NFkappa-B p105 subunit and p50 subunit.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM299
Conjugate
Unconjugated
Gene
NFKB1
Gene Alias
CVID12, DKFZp686C01211, DNA-binding factor KBF1, EBP-1, KBF1, MGC54151, NF kappaB1, NF KB, NFkappaB, NF-kappaB, NF-kappa-B, NF-kappaB p50, NF-kappaB1, NF-kappa-B1 p84/NF-kappa-B1 p98, NF-kappabeta, NF-kB, NFKB1, NF-KB1, NFKB-p105, NFKB-p50, nuclear factor, nuclear factor kappa b, nuclear factor kappa B subunit 1, nuclear factor kappa-B DNA binding subunit, nuclear factor kappaB p50, nuclear factor NF-kappa-B p105 subunit, Nuclear factor NF-kappa-B p50 subunit, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105, nuclear factor-kappaB p50, p105, p50, p50 subunit of NF kappaB, p50 subunit of NF-kappaB, p50/p105
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4790
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Specificity: reacts to human nuclear factor NF-kappaB p105 subunit and p50 subunit
- It may also react to mouse or rat NF-kappa-B p105/p50, as predicted by immunogen homology
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products
- It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation
- NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family
- It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains
- NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor
- NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning
- Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.