AMPK alpha-1,2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116552-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116552 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
AMPK alpha-1,2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PRKAA2
Gene Alias
2310008I11Rik; 5'-AMP-activated protein kinase alpha-1 catalytic subunit; 5'-AMP-activated protein kinase alpha-2 catalytic subunit; 5'-AMP-activated protein kinase catalytic alpha-2 subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; 63 kDa subunit; A830082D05; AAPK2; ACACA kinase; acetyl-CoA carboxylase kinase; AI194361; AI450832; AL024255; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase; AMP-activated protein kinase alpha 2; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK 63 kDa subunit; AMPK alpha 1; AMPK alpha 2; AMPK alpha-1 chain; AMPK alpha-2 cha
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
105787, 108079, 5562, 5563, 65248, 78975
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.49 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P54645, P54646, Q09137, Q13131, Q5EG47, Q8BRK8
Gene Symbols
PRKAA1, PRKAA2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 13-300 of human PRKAA1/PRKAA2 (NP_0062425)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa, NIH/3T3, PC-12, Mouse brain, Rat heart Immunogen sequence: AEKQKHDGRV KIGHYILGDT LGVGTFGKVK VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSSG VILYALLCGT LPFDDDHVPT LFKKICDGIF YTPQYLNPSV ISLLKHMLQV DPMKRATIKD IREHEWFKQD LPKYLFPEDP SYSSTMID The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK)
- AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits
- AMPK is an important energy-sensing enzyme that monitors cellular energy status
- In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol
- Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.